RT Journal Article SR Electronic T1 Association of Pharmacological Biomarkers with Treatment Response and Longterm Disability in Patients with Psoriatic Arthritis: Results from OUTPASS JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.190253 DO 10.3899/jrheum.190253 A1 Meghna Jani A1 Hector Chinoy A1 Anne Barton YR 2019 UL http://www.jrheum.org/content/early/2019/12/09/jrheum.190253.abstract AB Objective To identify (1) whether tumor necrosis factor inhibitor (TNFi) drug levels/anti-drug antibodies (ADAb) are associated with treatment response and disability in patients with psoriatic arthritis (PsA); and (2) the factors associated with TNFi drug levels. Methods Patients were recruited from a national multicenter prospective cohort with longitudinal serum samples and 28-joint count Disease Activity Scores (DAS28)/Health Assessment Questionnaire (HAQ) measurement over 12 months. Results Adalimumab (ADA) drug levels were significantly associated with ΔDAS28 (β 0.055, 95% CI 0.011–0.099; p = 0.014) and inversely with HAQ over 12 months (β –0.022, 95% CI –0.043 to –0.00063). Factors significantly associated with ADA drug levels were ADAb levels and body mass index. Conclusion Drug level testing in ADA-initiated PsA patients may be useful in determining treatment response/disability over 12 months.