RT Journal Article
SR Electronic
T1 Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 15
OP 19
DO 10.3899/jrheum.180832
VO 47
IS 1
A1 Philipp Sewerin
A1 Christoph Schleich
A1 Ralph Brinks
A1 Anja Müller-Lutz
A1 Florian Fichter
A1 Markus Eichner
A1 Matthias Schneider
A1 Benedikt Ostendorf
A1 Stefan Vordenbäumen
YR 2020
UL http://www.jrheum.org/content/47/1/15.abstract
AB Objective. To assess associations of synovial perfusion, cartilage quality, and outcome in rheumatoid arthritis (RA).Methods. Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling.Results. Synovial perfusion variables were associated with remission (p < 0.05) and cartilage quality (p < 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p < 0.05). Synovial perfusion improved in nonresponders over time (p < 0.05).Conclusion. Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA.