PT  - JOURNAL ARTICLE
AU  - Marieke Loef
AU  - Wendy Damman
AU  - Renée de Mutsert
AU  - Frits R.  Rosendaa
AU  - Margreet Kloppenburg
TI  - Health-related quality of life in patients with hand osteoarthritis from the general population and the outpatient clinic
AID  - 10.3899/jrheum.190781
DP  - 2019 Dec 01
TA  - The Journal of Rheumatology
PG  - jrheum.190781
4099  - http://www.jrheum.org/content/early/2019/11/25/jrheum.190781.short
4100  - http://www.jrheum.org/content/early/2019/11/25/jrheum.190781.full
AB  - Objective To investigate the association of hand osteoarthritis and concurrent hand and knee osteoarthritis with health-related quality of life (HRQoL) in the general population, and in patients consulting a rheumatology outpatient clinic. Methods In the population-based NEO study, participants were recruited from the greater area of Leiden. In the HOSTAS study, patients with a rheumatologist’s diagnosis of hand osteoarthritis were recruited from a Leiden-based hospital. In both cohorts, hand and knee osteoarthritis were defined by the ACR clinical criteria. In NEO, self-reported hospital-based specialist consultation for OA was recorded. Physical and mental HRQoL was assessed with normalised SF-36 scores. Associations were analysed using linear regression, adjusted for age, sex, education, ethnicity and BMI. Results Hand osteoarthritis alone and concurrent hand and knee osteoarthritis was present in 8% and 4% of 6,334 NEO participants, and in 57% and 32% of 538 HOSTAS patients. In NEO, hand osteoarthritis alone, and with knee osteoarthritis was associated with lower physical component summary (PCS) scores (mean difference (95% CI) -2.4 (-3.6; -1.3)) and -7.7 (-9.3; -6.2), respectively) compared with no osteoarthritis. Consulting a specialist was associated with worse PCS scores. In the HOSTAS cohort, mean PCS scores were lower than norm values (-3.5 and -7.9 for hand osteoarthritis and combined osteoarthritis, respectively). Mental HRQoL was not clinically relevantly associated in either cohort. Conclusion Hand osteoarthritis was associated with reduced physical, but not mental HRQoL in the general population and hospital patients. Physical HRQoL was further reduced in hospital care, and with concurrent knee osteoarthritis.