RT Journal Article
SR Electronic
T1 Menopause and Possible Effect on Association Between Age and Anticyclic Citrullinated Peptide Antibodies in Women At Risk of Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.190836
DO 10.3899/jrheum.190836
A1 Deshiré Alpizar-Rodriguez
A1 Axel Finckh
YR 2019
UL http://www.jrheum.org/content/early/2019/11/25/jrheum.190836.abstract
AB We read with interest the article by Berens, et al1 reporting that increasing age was associated with positivity for anticyclic citrullinated peptide antibodies (anti-CCP) 3.1 and anti-CCP–IgA in individuals at risk of rheumatoid arthritis (RA), that is, first-degree relatives (FDR) of patients with RA. We found similar results in a Swiss cohort of FDR: anticitrullinated protein antibodies (ACPA) positivity, particularly anti-CCP3.1, was associated with older age2. However, in contrast to Berens, et al1, we found a peak in prevalence in the age group of 45 to 55 years, particularly among women.