RT Journal Article
SR Electronic
T1 ANA-negative Antitopoisomerase I Antibody Is Not Generally Accepted
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.190524
DO 10.3899/jrheum.190524
A1 La-He Jearn
A1 Think-You Kim
YR 2019
UL http://www.jrheum.org/content/early/2019/07/23/jrheum.190524.abstract
AB Recently, Tebo and colleagues suggested that low titer antitopoisomerase I antibody (anti-topo I) including antinuclear antibody (ANA)-negative through multiplex bead assay can be of clinical significance and indicative of the pathogenesis of pulmonary epithelial damage1. This suggestion deeply worries us because it may have resulted from a lack of understanding of the methodology.