TY - JOUR T1 - ANA-negative Antitopoisomerase I Antibody Is Not Generally Accepted JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.190524 SP - jrheum.190524 AU - La-He Jearn AU - Think-You Kim Y1 - 2019/08/01 UR - http://www.jrheum.org/content/early/2019/07/23/jrheum.190524.abstract N2 - Recently, Tebo and colleagues suggested that low titer antitopoisomerase I antibody (anti-topo I) including antinuclear antibody (ANA)-negative through multiplex bead assay can be of clinical significance and indicative of the pathogenesis of pulmonary epithelial damage1. This suggestion deeply worries us because it may have resulted from a lack of understanding of the methodology. ER -