PT  - JOURNAL ARTICLE
AU  - La-He Jearn
AU  - Think-You Kim
TI  - ANA-negative Antitopoisomerase I Antibody Is Not Generally Accepted
AID  - 10.3899/jrheum.190524
DP  - 2019 Aug 01
TA  - The Journal of Rheumatology
PG  - jrheum.190524
4099  - http://www.jrheum.org/content/early/2019/07/23/jrheum.190524.short
4100  - http://www.jrheum.org/content/early/2019/07/23/jrheum.190524.full
AB  - Recently, Tebo and colleagues suggested that low titer antitopoisomerase I antibody (anti-topo I) including antinuclear antibody (ANA)-negative through multiplex bead assay can be of clinical significance and indicative of the pathogenesis of pulmonary epithelial damage1. This suggestion deeply worries us because it may have resulted from a lack of understanding of the methodology.