RT Journal Article SR Electronic T1 Increased cardiovascular risk and all-cause death in patients with Behçet’s disease: a nationwide population-based dynamic cohort study JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.190408 DO 10.3899/jrheum.190408 A1 Hyo-Suk Ahn A1 Dongjae Lee A1 Soo Young Lee A1 Yeong Ho Kim A1 Ji Hyun Lee A1 Dong Soo Yu A1 Kyung-Do Han A1 Yong Gyu Park A1 Young Bok Lee YR 2019 UL http://www.jrheum.org/content/early/2019/07/23/jrheum.190408.abstract AB Objective Behçet’s disease (BD) is a chronic inflammatory multiorgan disease. An increased risk of cardiovascular disease (CVD) and heightened death rate with BD have been suggested, but, to our knowledge, a nationwide large-scale study has not been conducted to date. This study aimed to determine the overall cardiovascular risk and death rate in BD patients versus controls using the Korean National Health Insurance Service (KNHIS) claim database. Methods Patients with BD (n = 5,576) with no previous history of CVD were selected from 2010 to 2014. An age- and sex-matched control population of individuals without BD (n = 27,880) was randomly sampled at a ratio of 5:1. Both cohorts were followed for incident CVD or all-cause death until 2015. Results : The risks of myocardial infarction [hazard ratio (HR): 1.72, 95% CI: 1.01–2.73] and stroke [HR: 1.65, 95% CI: 1.09–2.50] were significantly higher in BD patients than in control patients. BD patients also had a significantly higher risk of allcause death [HR: 1.82, 95% CI: 1.40–2.37] compared to controls. Conclusion Korean BD patients had a higher overall risk of CVD than did those without BD. Therefore, patients with BD must be carefully monitored for the potential development of CVD to ensure that appropriate early treatments are delivered.