PT  - JOURNAL ARTICLE
AU  - Pierluigi Macchioni
AU  - Carlo Salvarani
AU  - Niccolò Possemato
AU  - Marwin Gutierrez
AU  - Walter Grassi
AU  - Stefania Gasparini
AU  - Carlo Perricone
AU  - Fabio Massimo Perrotta
AU  - Rosa Daniela Grembiale
AU  - Caterina Bruno
AU  - Cesare Tripolino
AU  - Marcello Govoni
AU  - Giovanni Ciancio
AU  - Ilaria Farina
AU  - Roberta Ramonda
AU  - Paola Frallonardo
AU  - Francesca Desiati
AU  - Raffaele Scarpa
AU  - Luisa Costa
AU  - Alen Zabotti
AU  - Salvatore De Vita
AU  - Rita Maria D’Attino
AU  - Giuliana Gualberti
AU  - Rocco Merolla
AU  - Umberto di Luzio Paparatti
AU  - Raffaella Aldigeri
AU  - Antonio Marchesoni
TI  - Ultrasonographic and Clinical Assessment of Peripheral Enthesitis in Patients with Psoriatic Arthritis, Psoriasis, and Fibromyalgia Syndrome: The ULISSE Study
AID  - 10.3899/jrheum.171411
DP  - 2019 Aug 01
TA  - The Journal of Rheumatology
PG  - 904--911
VI  - 46
IP  - 8
4099  - http://www.jrheum.org/content/46/8/904.short
4100  - http://www.jrheum.org/content/46/8/904.full
SO  - J Rheumatol2019 Aug 01; 46
AB  - Objective. The purpose of the ULISSE study was to evaluate the prevalence of clinical and ultrasonographic (US) entheseal involvement in patients with psoriatic arthritis (PsA), psoriasis, and fibromyalgia syndrome (FMS).Methods. In this cross-sectional multicenter study, patients with PsA and psoriasis (not taking systemic therapy) and FMS underwent a clinical evaluation of the entheses, and a B-mode and power Doppler examination of 6 pairs of entheses.Results. The study analyzed 140 patients with PsA, 51 with psoriasis, and 51 with FMS. Clinical and US examinations were performed in 1960 and 1680 entheses in the PsA group, and 714 and 612 entheses both in the psoriasis group and in the FMS group. In both per-patient and per-enthesis evaluation, the frequency of entheseal tenderness was higher in patients with FMS (92% of the patients and 46% of the entheses, compared with 66%/23% in the PsA group and 59%/18% in the psoriasis group). With US examination, signs of entheseal involvement were more frequent in both the per-patient and per-enthesis evaluation in PsA and psoriasis (about 90% of patients in both the PsA and psoriasis groups and 75% of patients in the FMS group had at least 1 site affected, and 54%, 41%, and 27% of the pairs of entheses in, respectively, PsA, psoriasis, and FMS patients showed at least 1 enthesis involved).Conclusion. The ULISSE study indicated that enthesitis is a common feature in patients with PsA, those with psoriasis, and in those with FMS if only clinical examination is used. US entheseal assessment showed findings more consistent with the 3 disorders.