RT Journal Article SR Electronic T1 Outcome Domains, Outcome Measures, and Characteristics of Randomized Controlled Trials Testing Nonsurgical Interventions for Osteoarthritis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.180985 DO 10.3899/jrheum.180985 A1 Miso Krsticevic A1 Svjetlana Dosenovic A1 Daiana Anne-Marie Dimcea A1 Dominika Jedrzejewska A1 Ana Catarina Marques Lameirão A1 Eliana Santos Almeida A1 Antonia Jelicic Kadic A1 Milka Jeric Kegalj A1 Krste Boric A1 Livia Puljak YR 2019 UL http://www.jrheum.org/content/early/2019/06/11/jrheum.180985.abstract AB Objective Core outcome set (COS) is the minimum set of outcome domains that should be measured and reported in clinical trials. We analyzed outcome domains, prevalence of use of COS published by Outcome Measures in Rheumatology (OMERACT) initiative, outcome measures for outcome domains recommended by OMERACT COS, duration and size of randomized controlled trials (RCT) testing nonsurgical interventions for osteoarthritis (OA). Methods We searched PubMed and analyzed RCT about nonsurgical interventions for OA published from June 2012 to June 2017. We extracted data about trial type, use of OMERACT COS, efficacy outcome domains, safety outcome domains, outcome measures used for COS assessment, duration, and sample size. Results Among 334 analyzed trials, complete OMERACT-recommended COS was used by 14% of trials. Higher median prevalence of using OMERACT COS was found in trials explicitly described as phase III, and trials of pharmacological interventions with followup ≥ 1 year, but both with wide range of COS usage. Trialists used numerous different outcome measures for analyzing core outcome domains: 50 different outcome measures for pain, 74 for physical function, 9 for patient’s global assessment, and 5 for imaging. Conclusion Suboptimal use of recommended COS and heterogeneity of outcome measures is reducing quality and comparability of OA trials and hinders conclusions about efficacy and comparative efficacy of nonsurgical interventions. Interventions for improving study design of trials in this field would be beneficial.