TY - JOUR T1 - Anti-CCP3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.180897 SP - jrheum.180897 AU - Heather M. Berens AU - Kristen J. Polinski AU - Ted R. Mikuls AU - Sonia Khatter AU - Justin August AU - Ashley Visser AU - Michael Mahler AU - Michael Weisman AU - James R. O’Dell AU - Richard M. Keating AU - Jane H. Buckner AU - Peter K. Gregersen AU - Jill M. Norris AU - V. Michael Holers AU - Kevin D. Deane AU - M. Kristen Demoruelle Y1 - 2019/04/15 UR - http://www.jrheum.org/content/early/2019/04/09/jrheum.180897.abstract N2 - Objective We investigated the association of age and anti-cyclic citrullinated peptide (CCP) antibodies in subjects without RA. Methods Serum was tested for anti-CCP3.1 (IgG/IgA) in 678 first-degree relatives (FDRs) of RA patients and 330 osteoarthritis (OA) subjects. Individual isotypes (anti-CCPIgA and anti-CCP-IgG) were also tested in all FDRs. Results In FDRs, increasing age was significantly associated with positivity for anti-CCP3.1 (per year, OR=1.03) and anti-CCP-IgA (per year, OR=1.05) but not anti-CCPIgG. In FDRs and OA subjects, anti-CCP3.1 prevalence was significantly increased after age 50. Conclusion Increasing age in individuals without RA should be considered in the interpretation of anti-CCP3.1 positivity. ER -