TY - JOUR T1 - Presence of Antitopoisomerase I Antibody Alone May Not Be Sufficient for the Diagnosis of Systemic Sclerosis JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.180503 SP - jrheum.180503 AU - Anne E. Tebo AU - Robert L. Schmidt AU - Tracy M. Frech Y1 - 2019/03/01 UR - http://www.jrheum.org/content/early/2019/02/25/jrheum.180503.abstract N2 - Systemic sclerosis (SSc) is characterized by altered immune function and vascular damage, which lead to extensive fibrosis. Experts underscore the importance of using SSc-specific autoantibodies to divide the disease into subsets for prognosis, management, and research1,2. ER -