RT Journal Article
SR Electronic
T1 The SPECTRA Collaboration OMERACT Working Group: Criterion Validity of Joint Space Outcomes with High Resolution Peripheral Quantitative Computed Tomography
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.180870
DO 10.3899/jrheum.180870
A1 Sarah L.  Manske
A1 Scott C.  Brunet
A1 Stephanie Finzel
A1 Kathryn S.  Stok
A1 Philip G.  Conaghan
A1 Steven K.  Boyd
A1 Cheryl Barnabe
YR 2019
UL http://www.jrheum.org/content/early/2019/01/11/jrheum.180870.abstract
AB Objective We assessed construct validity of high-resolution peripheral quantitative computed tomography (HR-pQCT) joint space outcomes by comparison with radiographs in patients with rheumatoid arthritis. Methods In 43 patients, quantitative, volumetric, HR-pQCT measurements were compared with ordinal Sharp/van der Heijde scoring (SvdH) in the 2nd and 3rd metacarpophalangeal joints. Results Generalized estimating equations showed that joint space minimum, SD, and asymmetry by HR-pQCT were associated with SvdH scores (p < 0.05). There was a considerable range in HR-pQCT measurements at SvdH equal to 0. Conclusion HR-pQCT demonstrated construct validity outcomes and provides improved 3-D visualization of joint space.