PT  - JOURNAL ARTICLE
AU  - Sarah L.  Manske
AU  - Scott C.  Brunet
AU  - Stephanie Finzel
AU  - Kathryn S.  Stok
AU  - Philip G.  Conaghan
AU  - Steven K.  Boyd
AU  - Cheryl Barnabe
TI  - The SPECTRA Collaboration OMERACT Working Group: Criterion Validity of Joint Space Outcomes with High Resolution Peripheral Quantitative Computed Tomography
AID  - 10.3899/jrheum.180870
DP  - 2019 Jan 15
TA  - The Journal of Rheumatology
PG  - jrheum.180870
4099  - http://www.jrheum.org/content/early/2019/01/11/jrheum.180870.short
4100  - http://www.jrheum.org/content/early/2019/01/11/jrheum.180870.full
AB  - Objective We assessed construct validity of high-resolution peripheral quantitative computed tomography (HR-pQCT) joint space outcomes by comparison with radiographs in patients with rheumatoid arthritis. Methods In 43 patients, quantitative, volumetric, HR-pQCT measurements were compared with ordinal Sharp/van der Heijde scoring (SvdH) in the 2nd and 3rd metacarpophalangeal joints. Results Generalized estimating equations showed that joint space minimum, SD, and asymmetry by HR-pQCT were associated with SvdH scores (p < 0.05). There was a considerable range in HR-pQCT measurements at SvdH equal to 0. Conclusion HR-pQCT demonstrated construct validity outcomes and provides improved 3-D visualization of joint space.