RT Journal Article SR Electronic T1 Osteopontin and Disease Activity in Patients with Recent-onset Systemic Lupus Erythematosus: Results from the SLICC Inception Cohort JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.180713 DO 10.3899/jrheum.180713 A1 Lina Wirestam A1 Helena Enocsson A1 Thomas Skogh A1 Leonid Padyukov A1 Andreas Jönsen A1 Murray B. Urowitz A1 Dafna D. Gladman A1 Juanita Romero-Diaz A1 Sang-Cheol Bae A1 Paul R. Fortin A1 Jorge Sanchez-Guerrero A1 Ann E. Clarke A1 Sasha Bernatsky A1 Caroline Gordon A1 John G. Hanly A1 Daniel Wallace A1 David A. Isenberg A1 Anisur Rahman A1 Joan Merrill A1 Ellen Ginzler A1 Graciela S. Alarcón A1 W. Winn Chatham A1 Michelle Petri A1 Munther Khamashta A1 Cynthia Aranow A1 Meggan Mackay A1 Mary Anne Dooley A1 Susan Manzi A1 Rosalind Ramsey-Goldman A1 Ola Nived A1 Kristjan Steinsson A1 Asad Zoma A1 Guillermo Ruiz-Irastorza A1 Sam Lim A1 Ken Kalunian A1 Murat Inanc A1 Ronald van Vollenhoven A1 Manuel Ramos-Casals A1 Diane L. Kamen A1 Søren Jacobsen A1 Christine Peschken A1 Anca Askanase A1 Thomas Stoll A1 Ian N. Bruce A1 Jonas Wetterö A1 Christopher Sjöwall YR 2019 UL http://www.jrheum.org/content/early/2019/01/11/jrheum.180713.abstract AB Objective In cross-sectional studies, elevated osteopontin (OPN) levels have been proposed to reflect, and/or precede, progressive organ damage and disease severity in systemic lupus erythematosus (SLE). We aimed, in a cohort of patients with recent-onset SLE, to determine whether raised serum OPN levels precede damage and/or are associated with disease activity or certain disease phenotypes. Methods We included 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who had 5 years of followup data available. All patients fulfilled the 1997 American College of Rheumatology (ACR) criteria. Baseline sera from patients and from age- and sex-matched population-based controls were analyzed for OPN using ELISA. Disease activity and damage were assessed at each annual followup visit using the SLE Disease Activity Index 2000 (SLEDAI-2K) and the SLICC/ACR damage index (SDI), respectively. Results Compared to controls, baseline OPN was raised 4-fold in SLE cases (p < 0.0001). After relevant adjustments in a binary logistic regression model, OPN levels failed to significantly predict global damage accrual defined as SDI ≥ 1 at 5 years. However, baseline OPN correlated with SLEDAI-2K at enrollment into the cohort (r = 0.27, p < 0.0001), and patients with high disease activity (SLEDAI-2K ≥ 5) had raised serum OPN (p < 0.0001). In addition, higher OPN levels were found in patients with persistent disease activity (p = 0.0006), in cases with renal involvement (p < 0.0001) and impaired estimated glomerular filtration rate (p = 0.01). Conclusion The performance of OPN to predict development of organ damage was not impressive. However, OPN associated significantly with lupus nephritis and with raised disease activity at enrollment, as well as over time.