TY - JOUR T1 - Osteopontin and Disease Activity in Patients with Recent-onset Systemic Lupus Erythematosus: Results from the SLICC Inception Cohort JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.180713 SP - jrheum.180713 AU - Lina Wirestam AU - Helena Enocsson AU - Thomas Skogh AU - Leonid Padyukov AU - Andreas Jönsen AU - Murray B. Urowitz AU - Dafna D. Gladman AU - Juanita Romero-Diaz AU - Sang-Cheol Bae AU - Paul R. Fortin AU - Jorge Sanchez-Guerrero AU - Ann E. Clarke AU - Sasha Bernatsky AU - Caroline Gordon AU - John G. Hanly AU - Daniel Wallace AU - David A. Isenberg AU - Anisur Rahman AU - Joan Merrill AU - Ellen Ginzler AU - Graciela S. Alarcón AU - W. Winn Chatham AU - Michelle Petri AU - Munther Khamashta AU - Cynthia Aranow AU - Meggan Mackay AU - Mary Anne Dooley AU - Susan Manzi AU - Rosalind Ramsey-Goldman AU - Ola Nived AU - Kristjan Steinsson AU - Asad Zoma AU - Guillermo Ruiz-Irastorza AU - Sam Lim AU - Ken Kalunian AU - Murat Inanc AU - Ronald van Vollenhoven AU - Manuel Ramos-Casals AU - Diane L. Kamen AU - Søren Jacobsen AU - Christine Peschken AU - Anca Askanase AU - Thomas Stoll AU - Ian N. Bruce AU - Jonas Wetterö AU - Christopher Sjöwall Y1 - 2019/01/15 UR - http://www.jrheum.org/content/early/2019/01/11/jrheum.180713.abstract N2 - Objective In cross-sectional studies, elevated osteopontin (OPN) levels have been proposed to reflect, and/or precede, progressive organ damage and disease severity in systemic lupus erythematosus (SLE). We aimed, in a cohort of patients with recent-onset SLE, to determine whether raised serum OPN levels precede damage and/or are associated with disease activity or certain disease phenotypes. Methods We included 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who had 5 years of followup data available. All patients fulfilled the 1997 American College of Rheumatology (ACR) criteria. Baseline sera from patients and from age- and sex-matched population-based controls were analyzed for OPN using ELISA. Disease activity and damage were assessed at each annual followup visit using the SLE Disease Activity Index 2000 (SLEDAI-2K) and the SLICC/ACR damage index (SDI), respectively. Results Compared to controls, baseline OPN was raised 4-fold in SLE cases (p < 0.0001). After relevant adjustments in a binary logistic regression model, OPN levels failed to significantly predict global damage accrual defined as SDI ≥ 1 at 5 years. However, baseline OPN correlated with SLEDAI-2K at enrollment into the cohort (r = 0.27, p < 0.0001), and patients with high disease activity (SLEDAI-2K ≥ 5) had raised serum OPN (p < 0.0001). In addition, higher OPN levels were found in patients with persistent disease activity (p = 0.0006), in cases with renal involvement (p < 0.0001) and impaired estimated glomerular filtration rate (p = 0.01). Conclusion The performance of OPN to predict development of organ damage was not impressive. However, OPN associated significantly with lupus nephritis and with raised disease activity at enrollment, as well as over time. ER -