PT  - JOURNAL ARTICLE
AU  - Rianne E. van Bentum
AU  - Sjoerd C. Heslinga
AU  - Michael T. Nurmohamed
AU  - Andreas H. Gerards
AU  - Ed N. Griep
AU  - Charlotte B.J.M. Koehorst
AU  - Marc R. Kok
AU  - Anna M. Schilder
AU  - Marijn Verhoef
AU  - Irene E. van der Horst-Bruinsma
TI  - Reduced Occurrence Rate of Acute Anterior Uveitis in Ankylosing Spondylitis Treated with Golimumab — The GO-EASY Study
AID  - 10.3899/jrheum.180312
DP  - 2019 Feb 01
TA  - The Journal of Rheumatology
PG  - 153--159
VI  - 46
IP  - 2
4099  - http://www.jrheum.org/content/46/2/153.short
4100  - http://www.jrheum.org/content/46/2/153.full
SO  - J Rheumatol2019 Feb 01; 46
AB  - Objective. Acute anterior uveitis (AAU) is common in ankylosing spondylitis (AS). Golimumab (GOL), a tumor necrosis factor-α inhibitor (TNFi), has proven to be effective in the treatment of AS. To date, the effect of GOL on the incidence of AAU in AS is unknown. The objective was to study the AAU occurrence rate in patients with AS during GOL treatment and secondarily, the efficacy of GOL in daily clinical practice.Methods. The study was a multicenter prospective study in a real-world setting in patients with AS who were treated with GOL for 12 months. The occurrence of AAU was assessed in the year before the initial TNFi treatment and during GOL treatment and calculated for the period at risk for a new AAU. Measures for disease activity [Ankylosing Spondylitis Disease Activity Score (ASDAS)] and treatment response [Assessment of Spondyloarthritis international Society (ASAS20 score)] were collected.Results. In total, 93 patients (65% male, 55% TNFi-naive, 27% history of AAU) were included, with a median disease duration of 7 years and ASDAS score of 3.1. During GOL treatment, the AAU occurrence rate was reduced from 11.1 to 2.2 per 100 patient-years (rate-ratio 0.20, 95% CI 0.04–0.91). After 3 months of treatment, 41% of the patients experienced a clinically important improvement of the ASDAS score (p < 0.001) and 36% an ASDAS20 response (p < 0.001). At month 12, 49% had achieved an ASAS20 response (p < 0.001).Conclusion. In AS, the AAU occurrence rate and disease activity decreased significantly during GOL treatment. Therefore, GOL can be considered a good choice in patients with AS who need a TNFi, especially in cases of recurrent AAU. (EudraCT number: 2012-002458-21)