PT  - JOURNAL ARTICLE
AU  - Carson Chin
AU  - Eric C. Sayre
AU  - Ali Guermazi
AU  - Savvas Nicolaou
AU  - John M. Esdaile
AU  - Jacek Kopec
AU  - Anona Thorne
AU  - Joel Singer
AU  - Hubert Wong
AU  - Jolanda Cibere
TI  - Quadriceps Weakness and Risk of Knee Cartilage Loss Seen on Magnetic Resonance Imaging in a Population-based Cohort with Knee Pain
AID  - 10.3899/jrheum.170875
DP  - 2019 Feb 01
TA  - The Journal of Rheumatology
PG  - 198--203
VI  - 46
IP  - 2
4099  - http://www.jrheum.org/content/46/2/198.short
4100  - http://www.jrheum.org/content/46/2/198.full
SO  - J Rheumatol2019 Feb 01; 46
AB  - Objective. To determine whether baseline quadriceps weakness predicts cartilage loss assessed on magnetic resonance imaging (MRI).Methods. Subjects aged 40–79 with knee pain (n = 163) were recruited from a random population sample and examined for quadriceps weakness with manual isometric strength testing, using a 3-point scoring system (0 = poor resistance, 1 = moderate resistance, 2 = full resistance), which was dichotomized as normal (grade 2) versus weak (grade 0/1). MRI of the more symptomatic knee was obtained at baseline and at mean of 3.3 years. Cartilage was graded 0–4 on MRI. Exponential regression analysis was used to evaluate whether quadriceps weakness was associated with whole knee cartilage loss, and in secondary analyses with compartment-specific cartilage loss, adjusted for age, sex, body mass index, Western Ontario and McMaster Universities Osteoarthritis Arthritis Index pain score, and baseline MRI cartilage score.Results. Of 163 subjects, 54% were female, with a mean age of 57.7 years. Quadriceps weakness was seen in 11.9% of the subjects. Weakness was a predictor of whole knee cartilage loss (HR 3.48, 95% CI 1.30–9.35). Quadriceps weakness was associated with cartilage loss in the medial tibiofemoral (TF) compartment (HR 4.60, 95% CI 1.25–17.02), while no significant association was found with lateral TF (HR 1.53, 95% CI 0.24–9.78) or patellofemoral compartment (HR 2.76, 95% CI 0.46–16.44).Conclusion. In this symptomatic, population-based cohort, quadriceps weakness predicted whole knee and medial TF cartilage loss after 3 years. To our knowledge, this is the first study to show that a simple clinical examination of quadriceps strength can predict the risk of knee cartilage loss.