TY - JOUR T1 - Human Osteoblast-like Cells Are Permissive for Zika Virus Replication JF - The Journal of Rheumatology JO - J Rheumatol SP - 443 LP - 443 DO - 10.3899/jrheum.170835 VL - 45 IS - 3 AU - FRANCESCA COLAVITA AU - GIUSEPPINA MUSUMECI AU - CLAUDIA CAGLIOTI Y1 - 2018/03/01 UR - http://www.jrheum.org/content/45/3/443.abstract N2 - We read with great interest the letter by Roimicher, et al1. The authors reported a case of a woman with a 4-year diagnosis of rheumatoid arthritis who achieved therapy-induced clinical remission 4 months before acquiring Zika virus (ZIKV) infection. The woman presented with fever, maculopapular rush, conjunctivitis, and arthralgia, and was tested for Chikungunya virus and ZIKV infection. The ZIKV genome was detected in blood and knee synovial fluid (SF). ZIKV viremia become negative after the end of clinical signs (Day 7); however, the patient experienced articular pain about 1 week later, and tested positive for ZIKV RNA in SF, while ZIKV viremia remained negative. These findings characterized for the first time a ZIKV infection localized within the joint of a patient, and raised a more general … Address correspondence to Dr. C. Caglioti, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Laboratory of Virology, Via Portuense 292, Rome, Italy. E-mail: claudia.caglioti{at}inmi.it ER -