TY - JOUR T1 - An MIF Promoter Polymorphism Is Associated with Susceptibility to Pulmonary Arterial Hypertension in Diffuse Cutaneous Systemic Sclerosis JF - The Journal of Rheumatology JO - J Rheumatol SP - 1453 LP - 1457 DO - 10.3899/jrheum.161369 VL - 44 IS - 10 AU - Lara Bossini-Castillo AU - Diana Campillo-Davó AU - Elena López-Isac AU - Francisco David Carmona AU - Carmen P. Simeon AU - Patricia Carreira AU - José Luis Callejas-Rubio AU - Iván Castellví AU - Antonio Fernández-Nebro AU - Luis Rodríguez-Rodríguez AU - Manel Rubio-Rivas AU - Francisco J. García-Hernández AU - Ana Belén Madroñero AU - Lorenzo Beretta AU - Alessandro Santaniello AU - Claudio Lunardi AU - Paolo Airó AU - Anna-Maria Hoffmann-Vold AU - Alexander Kreuter AU - Gabriela Riemekasten AU - Torsten Witte AU - Nicolas Hunzelmann AU - Madelon C. Vonk AU - Alexandre E. Voskuyl AU - J. de Vries-Bouwstra AU - Paul Shiels AU - Ariane Herrick AU - Jane Worthington AU - Timothy R.D.J. Radstake AU - Javier Martin AU - The Spanish Scleroderma Group Y1 - 2017/10/01 UR - http://www.jrheum.org/content/44/10/1453.abstract N2 - Objective. Systemic sclerosis (SSc) is a fibrotic immune-mediated disease of unknown etiology. Among its clinical manifestations, pulmonary involvement is the leading cause of mortality in patients with SSc. However, the genetic factors involved in lung complication are not well defined. We aimed to review the association of the MIF gene, which encodes a cytokine implicated in idiopathic pulmonary hypertension among other diseases, with the susceptibility and clinical expression of SSc, in addition to testing the association of this polymorphism with SSc-related pulmonary involvement.Methods. A total of 4392 patients with SSc and 16,591 unaffected controls from 6 cohorts of European origin were genotyped for the MIF promoter variant rs755622. An inverse variance method was used to metaanalyze the data.Results. A statistically significant increase of the MIF rs755622*C allele frequency compared with controls was observed in the subgroups of patients with diffuse cutaneous SSc (dcSSc) and with pulmonary arterial hypertension (PAH) independently (dcSSc: p = 3.20E–2, OR 1.13; PAH: p = 2.19E–02, OR 1.32). However, our data revealed a stronger effect size with the subset of patients with SSc showing both clinical manifestations (dcSSc with PAH: p = 6.91E–3, OR 2.05).Conclusion. We reviewed the association of the MIF rs755622*C allele with SSc and described a phenotype-specific association of this variant with the susceptibility to develop PAH in patients with dcSSc. ER -