RT Journal Article
SR Electronic
T1 The OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging (MRI) Scoring System: Updated Recommendations by the OMERACT MRI in Arthritis Working Group
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.161433
DO 10.3899/jrheum.161433
A1 Mikkel Østergaard
A1 Charles G.  Peterfy
A1 Paul Bird
A1 Frédérique Gandjbakhch
A1 Daniel Glinatsi
A1 Iris Eshed
A1 Espen A.  Haavardsholm
A1 Siri Lillegraven
A1 Pernille Bøyesen
A1 Bo Ejbjerg
A1 Violaine Foltz
A1 Paul Emery
A1 Harry K.  Genant
A1 Philip G.  Conaghan
YR 2017
UL http://www.jrheum.org/content/early/2017/07/26/jrheum.161433.abstract
AB Objective The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, bone marrow edema/osteitis, and synovitis, was introduced in 2002, and is now the standard method of objectively quantifying inflammation and damage by MRI in RA trials. The objective of this paper was to identify subsequent advances and based on them, to provide updated recommendations for the RAMRIS. Methods MRI studies relevant for RAMRIS and technical and scientific advances were analyzed by the OMERACT MRI in Arthritis Working Group, which used these data to provide updated considerations on image acquisition, RAMRIS definitions, and scoring systems for the original and new RA pathologies. Further, a research agenda was outlined. Results Since 2002, longitudinal studies and clinical trials have documented RAMRIS variables to have face, construct, and criterion validity; high reliability and sensitivity to change; and the ability to discriminate between therapies. This has enabled RAMRIS to demonstrate inhibition of structural damage progression with fewer patients and shorter followup times than has been possible with conventional radiography. Technical improvements, including higher field strengths and improved pulse sequences, allow higher image resolution and contrast-to-noise ratio. These have facilitated development and validation of scoring methods of new pathologies: joint space narrowing and tenosynovitis. These have high reproducibility and moderate sensitivity to change, and can be added to RAMRIS. Combined scores of inflammation or joint damage may increase sensitivity to change and discriminative power. However, this requires further research. Conclusion Updated 2016 RAMRIS recommendations and a research agenda were developed.