RT Journal Article
SR Electronic
T1 Cryoglobulinemia in Sjögren Syndrome: A Disease Subset that Links Higher Systemic Disease Activity, Autoimmunity, and Local B Cell Proliferation in Mucosa-associated Lymphoid Tissue
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1179
OP 1183
DO 10.3899/jrheum.161465
VO 44
IS 8
A1 Luca Quartuccio
A1 Chiara Baldini
A1 Roberta Priori
A1 Elena Bartoloni
A1 Francesco Carubbi
A1 Alessia Alunno
A1 Saviana Gandolfo
A1 Serena Colafrancesco
A1 Roberto Giacomelli
A1 Roberto Gerli
A1 Guido Valesini
A1 Stefano Bombardieri
A1 Salvatore De Vita
YR 2017
UL http://www.jrheum.org/content/44/8/1179.abstract
AB Objective. To compare systemic disease activity by validated tools, i.e., the European League Against Rheumatism Sjögren Syndrome Disease Activity Index (ESSDAI) and the Clinical ESSDAI (ClinESSDAI) scores, between primary Sjögren syndrome (pSS) with positive serum cryoglobulins and pSS without serum cryoglobulins.Methods. There were 825 consecutive patients with pSS who were retrospectively evaluated.Results. The ESSDAI and the ClinESSDAI scores were significantly higher in cryoglobulin-positive patients (p < 0.0001, for both scores). Cryoglobulinemia was significantly associated with these domains: constitutional (p = 0.003), lymphadenopathy (p = 0.007), glandular (p = 0.0002), cutaneous (p < 0.0001), peripheral nervous system (p < 0.0001), hematological (p = 0.004), and biological (p < 0.0001).Conclusion. Cryoglobulin-positive patients show the highest systemic activity in pSS.