PT  - JOURNAL ARTICLE
AU  - Luca Quartuccio
AU  - Chiara Baldini
AU  - Roberta Priori
AU  - Elena Bartoloni
AU  - Francesco Carubbi
AU  - Alessia Alunno
AU  - Saviana Gandolfo
AU  - Serena Colafrancesco
AU  - Roberto Giacomelli
AU  - Roberto Gerli
AU  - Guido Valesini
AU  - Stefano Bombardieri
AU  - Salvatore De Vita
TI  - Cryoglobulinemia in Sjögren Syndrome: A Disease Subset that Links Higher Systemic Disease Activity, Autoimmunity, and Local B Cell Proliferation in Mucosa-associated Lymphoid Tissue
AID  - 10.3899/jrheum.161465
DP  - 2017 Aug 01
TA  - The Journal of Rheumatology
PG  - 1179--1183
VI  - 44
IP  - 8
4099  - http://www.jrheum.org/content/44/8/1179.short
4100  - http://www.jrheum.org/content/44/8/1179.full
SO  - J Rheumatol2017 Aug 01; 44
AB  - Objective. To compare systemic disease activity by validated tools, i.e., the European League Against Rheumatism Sjögren Syndrome Disease Activity Index (ESSDAI) and the Clinical ESSDAI (ClinESSDAI) scores, between primary Sjögren syndrome (pSS) with positive serum cryoglobulins and pSS without serum cryoglobulins.Methods. There were 825 consecutive patients with pSS who were retrospectively evaluated.Results. The ESSDAI and the ClinESSDAI scores were significantly higher in cryoglobulin-positive patients (p < 0.0001, for both scores). Cryoglobulinemia was significantly associated with these domains: constitutional (p = 0.003), lymphadenopathy (p = 0.007), glandular (p = 0.0002), cutaneous (p < 0.0001), peripheral nervous system (p < 0.0001), hematological (p = 0.004), and biological (p < 0.0001).Conclusion. Cryoglobulin-positive patients show the highest systemic activity in pSS.