@article {Measejrheum.160963, author = {Philip J. Mease and Chitra Karki and Jacqueline B. Palmer and Carol J. Etzel and Arthur Kavanaugh and Christopher T. Ritchlin and Wendi Malley and Vivian Herrera and Melody Tran and Jeffrey D. Greenberg}, title = {Clinical and Patient-reported Outcomes in Patients with Psoriatic Arthritis (PsA) by Body Surface Area Affected by Psoriasis: Results from the Corrona PsA/Spondyloarthritis Registry}, elocation-id = {jrheum.160963}, year = {2017}, doi = {10.3899/jrheum.160963}, publisher = {The Journal of Rheumatology}, abstract = {Objective Psoriatic arthritis (PsA) is commonly comorbid with psoriasis; the extent of skin lesions is a major contributor to psoriatic disease severity/burden. We evaluated whether extent of skin involvement with psoriasis [body surface area (BSA) \> 3\% vs <= 3\%] affects overall clinical and patient-reported outcomes (PRO) in patients with PsA. Methods Using the Corrona PsA/Spondyloarthritis Registry, patient characteristics, disease activity, and PRO at registry enrollment were assessed for patients with PsA aged >= 18 years with BSA \> 3\% versus <= 3\%. Regression models were used to evaluate associations of BSA level with outcome [modified minimal disease activity (MDA), Health Assessment Questionnaire (HAQ) score, patient-reported pain and fatigue, and the Work Productivity and Activity Impairment questionnaire score]. Adjustments were made for age, sex, race, body mass index, disease duration, and history of biologics, disease-modifying antirheumatic drug, and prednisone use. Results This analysis included 1240 patients with PsA with known BSA level (n = 451, BSA \> 3\%; n = 789, BSA <= 3\%). After adjusting for potential confounding variables, patients with BSA \> 3\% versus <= 3\% had greater patient-reported pain and fatigue and higher HAQ scores (p = 2.33 {\texttimes} 10{\textendash}8, p = 0.002, and p = 1.21 {\texttimes} 10{\textendash}7, respectively), were 1.7{\texttimes} more likely not to be in modified MDA (95\% CI 1.21{\textendash}2.41, p = 0.002), and were 2.1{\texttimes} more likely to have overall work impairment (1.37{\textendash}3.21, p = 0.0001). Conclusion These Corrona Registry data show that substantial skin involvement (BSA \> 3\%) is associated with greater PsA disease burden, underscoring the importance of assessing and effectively managing psoriasis in patients with PsA because this may be a contributing factor in PsA severity.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2017/06/09/jrheum.160963}, eprint = {https://www.jrheum.org/content/early/2017/06/09/jrheum.160963.full.pdf}, journal = {The Journal of Rheumatology} }