RT Journal Article SR Electronic T1 Whole-body Magnetic Resonance Imaging in Inflammatory Arthritis: Systematic Literature Review and First Steps Toward Standardization and an OMERACT Scoring System JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.161114 DO 10.3899/jrheum.161114 A1 Mikkel Østergaard A1 Iris Eshed A1 Christian E. Althoff A1 Rene P. Poggenborg A1 Torsten Diekhoff A1 Simon Krabbe A1 Sabine Weckbach A1 Robert G.W. Lambert A1 Susanne J. Pedersen A1 Walter P. Maksymowych A1 Charles G. Peterfy A1 Jane Freeston A1 Paul Bird A1 Philip G. Conaghan A1 Kay-Geert A. Hermann YR 2017 UL http://www.jrheum.org/content/early/2017/06/09/jrheum.161114.abstract AB Objective Whole-body magnetic resonance imaging (WB-MRI) is a relatively new technique that can enable assessment of the overall inflammatory status of people with arthritis, but standards for image acquisition, definitions of key pathologies, and a quantification system are required. Our aim was to perform a systematic literature review (SLR) and to develop consensus definitions of key pathologies, anatomical locations for assessment, a set of MRI sequences and imaging planes for the different body regions, and a preliminary scoring system for WB-MRI in inflammatory arthritis. Methods An SLR was initially performed, searching for WB-MRI studies in arthritis, osteoarthritis, spondyloarthritis, or enthesitis. These results were presented to a meeting of the MRI in Arthritis Working Group together with an MR image review. Following this, preliminary standards for WB-MRI in inflammatory arthritides were developed with further iteration at the Working Group meetings at the Outcome Measures in Rheumatology (OMERACT) 2016. Results The SLR identified 10 relevant original articles (7 cross-sectional and 3 longitudinal, mostly focusing on synovitis and/or enthesitis in spondyloarthritis, 4 with reproducibility data). The Working Group decided on inflammation in peripheral joints and entheses as primary focus areas, and then developed consensus MRI definitions for these pathologies, selected anatomical locations for assessment, agreed on a core set of MRI sequences and imaging planes for the different regions, and proposed a preliminary scoring system. It was decided to test and further develop the system by iterative multireader exercises. Conclusion These first steps in developing an OMERACT WB-MRI scoring system for use in inflammatory arthritides offer a framework for further testing and refinement.