PT  - JOURNAL ARTICLE
AU  - Gabriele Simonini
AU  - Claudia Bracaglia
AU  - Marco Cattalini
AU  - Andrea Taddio
AU  - Alice Brambilla
AU  - Cinzia De Libero
AU  - Denise Pires Marafon
AU  - Roberto Caputo
AU  - Rolando Cimaz
TI  - Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis
AID  - 10.3899/jrheum.161336
DP  - 2017 Apr 01
TA  - The Journal of Rheumatology
PG  - jrheum.161336
4099  - http://www.jrheum.org/content/early/2017/03/28/jrheum.161336.short
4100  - http://www.jrheum.org/content/early/2017/03/28/jrheum.161336.full
AB  - Objective To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment. Methods A retrospective, multicenter, cohort study. Results Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel- Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43). Conclusion Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.