TY - JOUR T1 - Longterm Outcomes of Renal Artery Involvement in Takayasu Arteritis JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.160974 SP - jrheum.160974 AU - Seokchan Hong AU - Byeongzu Ghang AU - Yong-Gil Kim AU - Chang-Keun Lee AU - Bin Yoo Y1 - 2017/02/15 UR - http://www.jrheum.org/content/early/2017/02/09/jrheum.160974.abstract N2 - Objective Takayasu arteritis (TA) involving the renal artery can result in hypertension (HTN), renal dysfunction, and premature death. The aim of this study was to investigate the longterm outcomes and factors that predict outcomes in patients with TA with renal artery stenosis. Methods The medical records of patients diagnosed with TA between January 1997 and December 2014 were reviewed retrospectively. Renal artery involvement was based on computed tomography and/or angiography findings. Poor outcome was defined as refractory HTN, chronic renal insufficiency, or death. Results Of the 62 TA patients with renal artery involvement, 11 (17.7%) underwent renal artery revascularization. Younger age, male sex, and more severe stenosis (> 70%) were associated with vascular intervention. After a median followup of 90.6 months, 11 (17.7%) of the 62 patients had refractory HTN and 6 (9.7%) had chronic renal insufficiency. Renal insufficiency [5/15 (33.3%) vs 3/47 (6.4%), p = 0.016] and bilateral involvement [12/15 (80.0%) vs 23/47 (48.9%), p = 0.041] were significantly more frequent in patients with poor than good outcomes. Multivariate Cox analysis revealed that renal insufficiency at presentation (HR 13.778, 95% CI 3.530–53.786, p < 0.001) and bilateral renal artery involvement (HR 5.053, 95% CI 1.179–21.661, p = 0.029) were significant risk factors for poor outcomes at followup, but performance of revascularization procedure was not (HR 0.663, 95% CI 0.176–2.498, p = 0.543). Conclusion Bilateral lesions and renal functional impairment at presentation, but not implementation of revascularization procedures, were significant factors for outcomes in TA patients with renal artery involvement. ER -