TY - JOUR T1 - Th17 and Interleukin 23 in the Pathogenesis of Psoriatic Arthritis and Spondyloarthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 15 LP - 18 DO - 10.3899/jrheum.120234 VL - 89 AU - ALBERTO CAULI AU - ALESSANDRO MATHIEU Y1 - 2012/07/01 UR - http://www.jrheum.org/content/89/15.abstract N2 - Psoriatic arthritis and spondyloarthritis (SpA) are complex immune-mediated diseases affecting peripheral and axial joints. T cells have been considered fundamental in triggering the disease and maintaining the process in the chronic phase. The recent discovery of the CD4+ Th17 lymphocyte subset and the interleukin 23/interleukin 17 axis has further contributed to the definition of unknown pathways, challenging previous models and the role of Th1/Th2 T cells in immune mediated diseases, including SpA. ER -