PT  - JOURNAL ARTICLE
AU  - ALBERTO CAULI
AU  - ALESSANDRO MATHIEU
TI  - Th17 and Interleukin 23 in the Pathogenesis of Psoriatic Arthritis and Spondyloarthritis
AID  - 10.3899/jrheum.120234
DP  - 2012 Jul 01
TA  - The Journal of Rheumatology
PG  - 15--18
VI  - 89
4099  - http://www.jrheum.org/content/89/15.short
4100  - http://www.jrheum.org/content/89/15.full
SO  - J Rheumatol2012 Jul 01; 89
AB  - Psoriatic arthritis and spondyloarthritis (SpA) are complex immune-mediated diseases affecting peripheral and axial joints. T cells have been considered fundamental in triggering the disease and maintaining the process in the chronic phase. The recent discovery of the CD4+ Th17 lymphocyte subset and the interleukin 23/interleukin 17 axis has further contributed to the definition of unknown pathways, challenging previous models and the role of Th1/Th2 T cells in immune mediated diseases, including SpA.