RT Journal Article
SR Electronic
T1 The Role of Inflammation in the Pathophysiology of Depression: Different Treatments and Their Effects
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 48
OP 54
DO 10.3899/jrheum.110903
VO 88
A1 FRANCIS E. LOTRICH
A1 HANI EL-GABALAWY
A1 LYN C. GUENTHER
A1 CARL F. WARE
YR 2011
UL http://www.jrheum.org/content/88/48.abstract
AB Compelling evidence suggests that inflammation contributes to the development of depression. Many depressed individuals have higher levels of proinflammatory mediators, which appear to interact with many of the pathophysiological domains of depression, including neuroendocrine function, neurotransmitter metabolism, and synaptic plasticity. This is further supported by observation that therapeutic administration of interferon-α (IFN-α) leads to depression in a significant proportion of patients. These findings suggest that targeting proinflammatory cytokines and their signaling pathways may represent a unique therapeutic opportunity to treat depression and related conditions, such as labile anger, irritability, and fatigue.