RT Journal Article
SR Electronic
T1 Tumor Necrosis Factor and Anti-Tumor Necrosis Factor Therapies
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 27
OP 39
DO 10.3899/jrheum.091463
VO 85
A1 EDWARD C. KEYSTONE
A1 CARL F. WARE
YR 2010
UL http://www.jrheum.org/content/85/27.abstract
AB Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states. This section discusses TNF, its receptors, and its role in immunoregulation and inflammation, as well as the currently available anti-TNF-based therapies.