RT Journal Article
SR Electronic
T1 Clinical Aspects and Comorbidities of Psoriasis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 19
OP 20
DO 10.3899/jrheum.090214
VO 83
A1 FABIO AYALA
A1 FABRIZIO AYALA
YR 2009
UL http://www.jrheum.org/content/83/19.abstract
AB Psoriasis is a disease mediated by Th1 and Th17 cytokines that has different phenotypes (plaque, guttate, pustular, and erythrodermic type). Aside from the well known psoriatic arthritis, associated disorders may occur more frequently than expected, including Crohn’s disease, anxiety/depression, and metabolic syndrome. This is based on a constellation of different factors, including abdominal obesity, atherogenic dyslipidemia, hypertension, and glucose intolerance, and is a strong predictor of type 2 diabetes, cardiovascular disease, and stroke. People with moderate to severe psoriasis have more risk for cardiac disease, presumably due to the inflammatory nature of psoriasis, causing inflammatory changes in coronary arteries. The strong association between psoriasis and obesity potentially makes psoriasis an important healthcare issue. Since cardiovascular risk factors are higher in psoriatic patients, dermatologists treating moderate to severe psoriasis should screen for their presence, thus approaching psoriasis as a potential multisystem disorder.