TY - JOUR T1 - Therapeutic Targets for Rheumatoid Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 1 LP - 1 DO - 10.3899/jrheum.090123 VL - 82 AU - EDWARD C. KEYSTONE AU - BOULOS HARAOUI Y1 - 2009/06/01 UR - http://www.jrheum.org/content/82/1.abstract N2 - Rheumatoid arthritis (RA) is a chronic, often debilitating disease characterized by inflammation and progressive joint damage. In recent years, there have been promising advancements in the treatment of RA. Improved understanding of the intercellular and intracellular pathways involved in the pathogenesis of RA has clarified the role of the classic disease modifying antirheumatic drugs (DMARD) and allowed the identification of novel targets for a group of drugs called biologic response modifiers, or biologics.The pathogenesis … ER -