TY - JOUR T1 - New Approaches in Tumor Necrosis Factor Antagonism for the Treatment of Psoriatic Arthritis: Certolizumab Pegol JF - The Journal of Rheumatology JO - J Rheumatol SP - 70 LP - 72 DO - 10.3899/jrheum.150641 VL - 93 AU - Alberto Cauli AU - Matteo Piga AU - Ennio Lubrano AU - Antonio Marchesoni AU - Alberto Floris AU - Alessandro Mathieu Y1 - 2015/11/01 UR - http://www.jrheum.org/content/93/70.abstract N2 - The pathogenesis of psoriatic arthritis (PsA) is still under discussion but great advances have been made in the last 2 decades that confirm the central role of tumor necrosis factor-α (TNF-α) in its inflammatory milieu. New therapeutic approaches have been proposed, and new molecules with anti-TNF-α activity have been chemically altered to improve their pharmacological properties. Certolizumab pegol (CZP) is a PEGylated Fc-free anti-TNF that has been shown clinically to be effective in the treatment of rheumatoid arthritis (RA), skin psoriasis, and PsA. This article summarizes available data on its clinical efficacy and safety profile in the treatment of patients with PsA. ER -