TY - JOUR T1 - Psoriatic Disease: Clinical Staging JF - The Journal of Rheumatology JO - J Rheumatol SP - 24 LP - 26 DO - 10.3899/jrheum.150629 VL - 93 AU - Raffaele Scarpa AU - Francesco Caso AU - Luisa Costa AU - Rosario Peluso AU - Angelo Spanò AU - Ennio Lubrano AU - Antonio Del Puente AU - John M.H. Moll Y1 - 2015/11/01 UR - http://www.jrheum.org/content/93/24.abstract N2 - In 2006, the introduction of the concept “psoriatic disease” (PsD) extended the traditional idea of a condition confined to skin and joints. Now we consider PsD a systemic condition, in which the increased activity of tumor necrosis factor acts as the most potent engine for a series of molecular interactions. These lead not only to the genesis of skin and joint symptoms, but also to other clinical aspects such as inflammatory bowel disease, eye involvement, and metabolic syndrome. The blocking of a precise molecular target has dramatically modified therapeutic strategies, making possible adequate control of all the clinical aspects of the condition. Therefore, an expanded clinical staging of patients could now be considered in order to ensure the best therapeutic approach and prognosis. ER -