PT  - JOURNAL ARTICLE
AU  - Katerina Laskari
AU  - Panagiota Boura
AU  - George Ν.  Dalekos
AU  - Alexandros Garyfallos
AU  - Dimitrios Karokis
AU  - Dimitrios Pikazis
AU  - Loukas Settas
AU  - Grigoris Skarantavos
AU  - Elena Tsitsami
AU  - Petros Ρ.  Sfikakis
TI  - Longterm Beneficial Effect of Canakinumab in Colchicine-resistant Familial Mediterranean Fever
AID  - 10.3899/jrheum.160518
DP  - 2016 Nov 15
TA  - The Journal of Rheumatology
PG  - jrheum.160518
4099  - http://www.jrheum.org/content/early/2016/11/09/jrheum.160518.short
4100  - http://www.jrheum.org/content/early/2016/11/09/jrheum.160518.full
AB  - Objective To assess the efficacy and safety of the interleukin-1β (IL-1β) inhibitor canakinumab in all adolescent and adult patients with familial Mediterranean fever (FMF) identified from the Greek National Registry for off-label drug use between 2010 and 2015. Methods In this retrospective longitudinal outcome study, clinical and laboratory data were collected from 14 patients (7 men) aged median 38.5 years (range 13–70), with median disease duration of 14 years, and active FMF despite colchicine (n = 9) or both colchicine and anakinra (n = 5). Results All patients continued to receive canakinumab at last visit (median of 18 mos, range 13–53), which was initially given as monotherapy (n = 8) or in combination with colchicine and/or corticosteroids, every 4 (n = 7), 6 (n = 2), or 8 weeks (n = 5). Eleven patients (79%), including 6 receiving monotherapy, achieved complete clinical remission within 2 months (median), while normalization of all laboratory variables denoting inflammation occurred in 92% at 3 months (median). The remaining 3 patients achieved partial responses. Responses were sustained in all but 4 patients, who relapsed. Reducing the canakinumab administration interval from 8 or 6 weeks to 4 weeks led to suppression of disease activity in the relapsing patients. On the other hand, drug administration interval could be safely increased in 2 patients in remission. Corticosteroid doses were significantly reduced during followup. Canakinumab was well tolerated; 1 patient experienced a urinary tract infection and another one a viral gastroenteritis. Conclusion Treatment with canakinumab in an individualized dosing scheme results in rapid and sustained remission in colchicine-resistant FMF.