TY - JOUR T1 - Knee Pain Predicts Subsequent Shoulder Pain and the Association Is Mediated by Leg Weakness: Longitudinal Observational Data from the Osteoarthritis Initiative JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.160001 SP - jrheum.160001 AU - Laura L. Laslett AU - Petr Otahal AU - Elizabeth M.A. Hensor AU - Sarah R. Kingsbury AU - Philip G. Conaghan Y1 - 2016/10/01 UR - http://www.jrheum.org/content/early/2016/09/27/jrheum.160001.abstract N2 - Objective To assess whether the “spread” of joint pain is related to pain-associated muscle loss in 1 joint leading to increased loading and subsequent pain in other joints. Methods Associations between persistent knee pain (pain in 1 or 2 knees over 0–3 years vs no persistent pain) and incident shoulder pain at Year 4 were examined in participants from the longitudinal National Institutes of Health Osteoarthritis Initiative. Associations were assessed using log multinomial modeling, adjusted for age, sex, body mass index, depression score, other lower limb pain, and baseline leg weakness (difficulty standing from a sitting position). Results In older adults with clinically significant knee osteoarthritis (OA) or at risk of knee OA (n = 3486), the number of painful joints increased yearly, from 2.1 joints (95% CI 2.0–2.2) at baseline increasing by 5.2% (95% CI 2.2–8.3) at Year 4. Shoulders were the next most commonly affected joints after knees (28.5%). Persistent pain in 1 or 2 knees increased risk of bilateral shoulder pain at Year 4 [1 knee: relative risk (RR) 1.59, 95% CI 0.97–2.61; 2 knees: RR 2.02, 95% CI 1.17–3.49] after adjustment for confounders. Further adjustment for leg weakness attenuated effect sizes (1 knee: RR 1.13, 95% CI 0.60–2.11; 2 knees: RR 1.44, 95% CI 0.75–2.77), indicating mediation by functional leg weakness. Conclusion Spread of joint pain is not random. Persistently painful knees predict new bilateral shoulder pain, which is likely mediated by leg weakness, suggesting that biomechanical factors influence the spread of pain. ER -