TY - JOUR T1 - Analysis of Systemic Sclerosis-associated Genes in a Turkish Population JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.160045 SP - jrheum.160045 AU - F. David Carmona AU - Ahmet Mesut Onat AU - Tamara Fernández-Aranguren AU - Alberto Serrano-Fernández AU - Gema Robledo AU - Haner Direskeneli AU - Amr H. Sawalha AU - Sule Yavuz AU - Javier Martín Y1 - 2016/05/01 UR - http://www.jrheum.org/content/early/2016/04/22/jrheum.160045.abstract N2 - Objective To evaluate the genetic background of systemic sclerosis (SSc) in the Turkish population. Methods There were 354 cases and 718 unaffected controls from Turkey genotyped for the most relevant SSc genetic markers (IRF5-rs10488631, STAT4-rs3821236, CD247-rs2056626, DNASE1L3-rs35677470, IL12A-rs77583790, and ATG5-rs9373839). Association tests were conducted to identify possible associations. Results Except for ATG5, all the analyzed genes showed either significant associations (IRF5: p = 1.32E–05, OR 1.76; CD247: p = 2.20E–03, OR 0.75) or trends of association (STAT4: p = 0.066, OR 1.21; IL12A: p = 0.079, OR 4.07; DNASE1L3: p = 0.097, OR 1.41) with the overall disease or with specific phenotypes. Conclusion The genetic component of SSc seems to be similar between Turks and Europeans. ER -