PT - JOURNAL ARTICLE AU - Adem Aksoy AU - Dilek Solmaz AU - Gercek Can AU - Pinar Cetin AU - Ali Balci AU - Servet Akar AU - Merih Birlik AU - Nurullah Akkoc AU - Fatos Onen TI - Increased Frequency of Hand Osteoarthritis in Patients with Primary Sjögren Syndrome Compared with Systemic Lupus Erythematosus AID - 10.3899/jrheum.150841 DP - 2016 Apr 01 TA - The Journal of Rheumatology PG - jrheum.150841 4099 - http://www.jrheum.org/content/early/2016/03/28/jrheum.150841.short 4100 - http://www.jrheum.org/content/early/2016/03/28/jrheum.150841.full AB - Objective In daily practice, we noticed that hand osteoarthritis (OA) was commonly associated with primary Sjögren syndrome (pSS). Therefore, we aimed to investigate its prevalence in patients with pSS in a controlled study. Methods The study included patients with pSS and controls with systemic lupus erythematosus (SLE). Standard hand/wrist radiographs were obtained and classified according to the Kellgren-Lawrence system. “Erosive hand OA” was defined according to the Verbruggen-Veys classification. Results There were 114 patients with pSS (110 women, 51.0 yrs) and 34 patients with SLE (33 women, 42.4 yrs). Among 114 patients with pSS, 42.7% had radiographic, 30.3% symptomatic, and 16.0% erosive hand OA. The prevalences of radiographic (45.5%) and erosive hand OA (14.4%) in 90 patients with pSS with age- and sex-matched patients with SLE were significantly higher than those in patients with SLE (14.7% and 0.0%, p = 0.007 and p = 0.012, respectively). Interobserver reliabilities for diagnosing radiographic and erosive OA were found to be good (ĸ = 0.780 and ĸ = 0.788, respectively). Intraobserver reliabilities for diagnosing radiographic and erosive OA were also good (ĸ = 0.784 and ĸ = 0.825 for FO, and ĸ = 0.722 and ĸ = 0.800 for AB, respectively). The frequency of hand OA in patients with pSS was found to be increased with increasing age (r = 0.513). The mean age of those with erosive hand OA was significantly higher than those without erosive OA (p < 0.001). Conclusion This study suggests that pSS, conversely to SLE, is more frequently associated with hand OA.