RT Journal Article
SR Electronic
T1 Magnetic Resonance Imaging Findings following Intraarticular Infliximab Therapy for Refractory Temporomandibular Joint Arthritis among Children with Juvenile Idiopathic Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.150308
DO 10.3899/jrheum.150308
A1 Matthew Laurence  Stoll
A1 Yoginder Nath  Vaid
A1 Saurabh Guleria
A1 Timothy Beukelman
A1 Peter Daniel  Waite
A1 Randy Quentin  Cron
YR 2015
UL http://www.jrheum.org/content/early/2015/08/26/jrheum.150308.abstract
AB Objective To evaluate the involvement of intraarticular (IA) infliximab (IFX) in the management of temporomandibular joint (TMJ) arthritis associated with juvenile idiopathic arthritis (JIA) that is refractory to systemic treatment and IA corticosteroid therapy. Methods Ours was a retrospective study of children with JIA who received IA IFX into the TMJ. The effectiveness of treatment on the progression of acute and chronic changes was assessed by a quantitative magnetic resonance imaging scoring system. Results Median acute and chronic scores worsened by 0.25 and 0.75, respectively. In multivariate analysis, worsening acute scores and passage of time predicted worsening of the chronic scores. Conclusion IA IFX allowed for progression of refractory TMJ arthritis in most but not all children with JIA.