TY - JOUR T1 - Serum Vascular Endothelial Growth Factor Levels Lack Predictive Value in Patients with Active Ankylosing Spondylitis Treated with Golimumab JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.150897 SP - jrheum.150897 AU - Jürgen Braun AU - Xenofon Baraliakos AU - Kay-Geert A. Hermann AU - Stephen Xu AU - Benjamin Hsu Y1 - 2016/03/01 UR - http://www.jrheum.org/content/early/2016/02/24/jrheum.150897.abstract N2 - Objective To assess vascular endothelial growth factor (VEGF) correlations with new bone formation and bone marrow edema in patients with ankylosing spondylitis (AS) treated with golimumab (GOL). Methods Following placebo control (through weeks 16 and 24), GO-RAISE (A Multicenter Randomized, Double-blind, Placebo-controlled Trial of Golimumab, a Fully Human Anti-TNF-α Monoclonal Antibody, Administered Subcutaneously, in Subjects with Active Ankylosing Spondylitis; ClinicalTrials.gov: NCT00265083) all patients received GOL; sera/images were available at weeks 0, 104, and 208. Lateral spinal radiographs and magnetic resonance imaging (MRI) were scored using the modified Stokes Ankylosing Spondylitis Spine Score (mSASSS) and the Ankylosing Spondylitis Spinal MRI activity score, respectively. Results VEGF levels and the mSASSS did not significantly correlate. Logistic regression analyses showed no association between VEGF levels and an increased risk of syndesmophyte formation at weeks 104 and 208. Pretreatment/Week 14 VEGF did not predict MRI scores/changes at Week 104. Conclusion Serum VEGF did not predict radiographic progression/spinal inflammation in patients receiving antitumor necrosis factor. ER -