RT Journal Article
SR Electronic
T1 Common Variants of cGKII/PRKG2 Are Not Associated with Gout Susceptibility
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.131548
DO 10.3899/jrheum.131548
A1 Masayuki Sakiyama
A1 Hirotaka Matsuo
A1 Toshinori Chiba
A1 Akiyoshi Nakayama
A1 Takahiro Nakamura
A1 Seiko Shimizu
A1 Emi Morita
A1 Nana Fukuda
A1 Hiroshi Nakashima
A1 Yutaka Sakurai
A1 Kimiyoshi Ichida
A1 Toru Shimizu
A1 Nariyoshi Shinomiya
YR 2014
UL http://www.jrheum.org/content/early/2014/05/28/jrheum.131548.abstract
AB Objective Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (cGKII/PRKG2) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population. Methods Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was performed in 741 male gout patients and 1302 male controls. Results cGKII variants have no association with gout. Conclusion Our replication study suggests that cGKII is not involved in gout susceptibility.