RT Journal Article SR Electronic T1 Common Variants of cGKII/PRKG2 Are Not Associated with Gout Susceptibility JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.131548 DO 10.3899/jrheum.131548 A1 Masayuki Sakiyama A1 Hirotaka Matsuo A1 Toshinori Chiba A1 Akiyoshi Nakayama A1 Takahiro Nakamura A1 Seiko Shimizu A1 Emi Morita A1 Nana Fukuda A1 Hiroshi Nakashima A1 Yutaka Sakurai A1 Kimiyoshi Ichida A1 Toru Shimizu A1 Nariyoshi Shinomiya YR 2014 UL http://www.jrheum.org/content/early/2014/05/28/jrheum.131548.abstract AB Objective Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (cGKII/PRKG2) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population. Methods Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was performed in 741 male gout patients and 1302 male controls. Results cGKII variants have no association with gout. Conclusion Our replication study suggests that cGKII is not involved in gout susceptibility.