@article {Sakiyamajrheum.131548, author = {Masayuki Sakiyama and Hirotaka Matsuo and Toshinori Chiba and Akiyoshi Nakayama and Takahiro Nakamura and Seiko Shimizu and Emi Morita and Nana Fukuda and Hiroshi Nakashima and Yutaka Sakurai and Kimiyoshi Ichida and Toru Shimizu and Nariyoshi Shinomiya}, title = {Common Variants of cGKII/PRKG2 Are Not Associated with Gout Susceptibility }, elocation-id = {jrheum.131548}, year = {2014}, doi = {10.3899/jrheum.131548}, publisher = {The Journal of Rheumatology}, abstract = {Objective Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (cGKII/PRKG2) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population. Methods Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was performed in 741 male gout patients and 1302 male controls. Results cGKII variants have no association with gout. Conclusion Our replication study suggests that cGKII is not involved in gout susceptibility.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2014/05/28/jrheum.131548}, eprint = {https://www.jrheum.org/content/early/2014/05/28/jrheum.131548.full.pdf}, journal = {The Journal of Rheumatology} }