RT Journal Article
SR Electronic
T1 Comparison of Labial Minor Salivary Gland Biopsies from Childhood Sjögren Syndrome and Age-matched Controls
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.131511
DO 10.3899/jrheum.131511
A1 Naoto Yokogawa
A1 Scott M.  Lieberman
A1 Faizan Alawi
A1 Sharon Bout-Tabaku
A1 Marta Guttenberg
A1 David D.  Sherry
A1 Frederick B.  Vivino
YR 2014
UL http://www.jrheum.org/content/early/2014/04/28/jrheum.131511.abstract
AB Objective To determine an appropriate focus score cutoff for childhood Sjögren syndrome (SS). Methods Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist. Results The presence of any focal sialadenitis (focus score > 0 foci/4 mm2) was common among childhood SS samples but present in only 1 of 8 control samples. Conclusion The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.