TY - JOUR T1 - Are Baseline High Molecular Weight Adiponectin Levels Associated with Radiographic Progression in Rheumatoid Arthritis and Osteoarthritis? JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.130888 SP - jrheum.130888 AU - Inge R. Klein-Wieringa AU - Stefan N. Andersen AU - Linda Herb-van Toorn AU - Joanneke C. Kwekkeboom AU - Anette H.M. van der Helm-van Mil AU - Ingrid Meulenbelt AU - Tom W.J. Huizinga AU - Margreet Kloppenburg AU - René E.M. Toes AU - Andreea Ioan-Facsinay Y1 - 2014/04/01 UR - http://www.jrheum.org/content/early/2014/03/26/jrheum.130888.abstract N2 - Objective To investigate whether high molecular weight adiponectin (hmwAPN) mediates the associations of total adiponectin (totAPN) with radiographic progression in rheumatoid arthritis (RA) and hand osteoarthritis (HOA). Methods Associations between baseline hmwAPN or totAPN levels with radiographic progression were determined using multivariate linear regression or generalized estimated equations. Results In patients with RA, totAPN associated positively, whereas in patients with HOA it associated negatively with radiographic progression. In contrast, hmwAPN did not associate significantly with radiographic progression in either cohort. Conclusion Our data indicate that the differential effects associated between totAPN and radiographic progression in either RA or HOA are not mediated by hmwAPN. ER -