RT Journal Article
SR Electronic
T1 American College of Rheumatology Criteria at Inception, and Accrual over 5 Years in the SLICC Inception Cohort
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.130704
DO 10.3899/jrheum.130704
A1 Murray B.  Urowitz
A1 Dafna D.  Gladman
A1 Dominique Ibañez
A1 Jorge Sanchez-Guerrero
A1 Juanita Romero-Diaz
A1 Caroline Gordon
A1 Sang-Cheol Bae
A1 Anne E.  Clarke
A1 Sasha Bernatsky
A1 Paul R.  Fortin
A1 John G.  Hanly
A1 David Isenberg
A1 Anisur Rahman
A1 Daniel J.  Wallace
A1 Ellen Ginzler
A1 Michelle Petri
A1 Ian N.  Bruce
A1 Joan T.  Merrill
A1 Ola Nived
A1 Gunnar Sturfelt
A1 Mary Anne  Dooley
A1 Graciela S.  Alarcón
A1 Barri Fessler
A1 Kristjan Steinsson
A1 Rosalind Ramsey-Goldman
A1 Asad Zoma
A1 Munther Khamashta
A1 Susan Manzi
A1 Ronald van Vollenhoven
A1 Manuel Ramos-Casals
A1 Cynthia Aranow
A1 Thomas Stoll
YR 2014
UL http://www.jrheum.org/content/early/2014/03/26/jrheum.130704.abstract
AB Objective To determine the frequency of each American College of Rheumatology (ACR) criterion met at time of enrollment, and the increase in each of the criteria over 5 years. Methods In 2000 the Systemic Lupus International Collaborating Clinics (SLICC) recruited an international inception cohort of patients with systemic lupus erythematosus (SLE; ≥ 4 ACR criteria) who were followed at yearly intervals according to a standard protocol. Descriptive statistics were used to assess the total and cumulative number of ACR criteria met at each visit. Regression models were done to compare the increase of individual and cumulative criteria as a function of race/ethnicity group, and sex. Results In all, 768 patients have been followed for a minimum of 5 years. Overall, 59.1% of the patients had an increase in the number of ACR criteria they met over the 5-year period. The mean number of ACR criteria met at enrollment was 5.04 ± 1.13 and at year 5 was 6.03 ± 1.42. At enrollment, nonwhite patients had a higher number of ACR criteria (5.19 ± 1.23) than white patients. The total number of criteria increased in both white and nonwhite ethnicities, but increased more among whites. Males had a slightly lower number of criteria at enrollment compared to females and males accrued fewer criteria at 5 years. Conclusion In this international inception cohort of SLE patients with at least 4 ACR criteria at entry, there was an accumulation of ACR criteria over the following 5 years. The distribution of criteria both at inception and over 5 years is affected by sex and ethnicity.