RT Journal Article
SR Electronic
T1 Levels in Plasma of the Serine Proteases and Associated Proteins of the Lectin Pathway Are Altered in Patients with Systemic Lupus Erythematosus
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.141163
DO 10.3899/jrheum.141163
A1 Anne Troldborg
A1 Steffen Thiel
A1 Magdalena Janina  Laska
A1 Bent Deleuran
A1 Jens Christian  Jensenius
A1 Kristian Stengaard-Pedersen
YR 2015
UL http://www.jrheum.org/content/early/2015/04/09/jrheum.141163.abstract
AB Objective To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis. Methods Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC). Results Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133). Conclusion In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.