TY - JOUR T1 - Levels in Plasma of the Serine Proteases and Associated Proteins of the Lectin Pathway Are Altered in Patients with Systemic Lupus Erythematosus JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.141163 SP - jrheum.141163 AU - Anne Troldborg AU - Steffen Thiel AU - Magdalena Janina Laska AU - Bent Deleuran AU - Jens Christian Jensenius AU - Kristian Stengaard-Pedersen Y1 - 2015/04/15 UR - http://www.jrheum.org/content/early/2015/04/09/jrheum.141163.abstract N2 - Objective To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis. Methods Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC). Results Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133). Conclusion In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis. ER -