PT  - JOURNAL ARTICLE
AU  - Hong Meng
AU  - Gang Liu
AU  - Jianlong Zhai
AU  - Yuzhi Zhen
AU  - Qingzhen Zhao
AU  - Mingqi Zheng
AU  - Guoping Ma
AU  - Le Wang
AU  - Li Tian
AU  - Lishuang Ji
AU  - Linan Duan
AU  - Lizhuo Li
AU  - Kunshen Liu
AU  - Chao Liu
TI  - Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients with Hyperuricemia — The PUSH-PATH3 Study
AID  - 10.3899/jrheum.141037
DP  - 2015 Mar 15
TA  - The Journal of Rheumatology
PG  - jrheum.141037
4099  - http://www.jrheum.org/content/early/2015/03/10/jrheum.141037.short
4100  - http://www.jrheum.org/content/early/2015/03/10/jrheum.141037.full
AB  - Objective To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia. Methods Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid > 7 mg/dl). Results Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p < 0.01) and serum creatinine by 0.17 mg/dl (p < 0.01). These favorable effects were associated with a remarkable increase in urine output, improvement in renal function, and improvement in clinical status. Conclusion Prednisone can be used safely in symptomatic HF patients with hyperuricemia.