@article {Mengjrheum.141037, author = {Hong Meng and Gang Liu and Jianlong Zhai and Yuzhi Zhen and Qingzhen Zhao and Mingqi Zheng and Guoping Ma and Le Wang and Li Tian and Lishuang Ji and Linan Duan and Lizhuo Li and Kunshen Liu and Chao Liu}, title = {Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients with Hyperuricemia {\textemdash} The PUSH-PATH3 Study}, elocation-id = {jrheum.141037}, year = {2015}, doi = {10.3899/jrheum.141037}, publisher = {The Journal of Rheumatology}, abstract = {Objective To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia. Methods Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid \> 7 mg/dl). Results Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p \< 0.01) and serum creatinine by 0.17 mg/dl (p \< 0.01). These favorable effects were associated with a remarkable increase in urine output, improvement in renal function, and improvement in clinical status. Conclusion Prednisone can be used safely in symptomatic HF patients with hyperuricemia.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2015/03/10/jrheum.141037}, eprint = {https://www.jrheum.org/content/early/2015/03/10/jrheum.141037.full.pdf}, journal = {The Journal of Rheumatology} }